High childhood serum triglyceride concentrations associate with hepatocellular adenoma development in patients with glycogen storage disease type Ia.

Haring MPD, Peeks F, Oosterveer MH, Brouwers MCGJ, Hollak CEM, Janssen MCH, Langendonk JG, Rennings AJM, Wagenmakers MAEM, Verkade HJ, Derks TGJ, de Meijer VE

JHEP reports : innovation in hepatology, 2022 Aug


Glycogen storage disease type Ia (GSDIa) is an inborn error of carbohydrate metabolism caused by pathogenic variants in the glucose-6-phosphatase catalytic subunit 1 () gene and is associated with hepatocellular adenoma (HCA) formation. Data on risk factors for HCA occurrence in GSDIa are scarce. We investigated HCA development in relation to sex, genotype, and serum triglyceride concentration (TG).

doi: 10.1016/j.jhepr.2022.100512