Seizure due to Lamotrigine Underexposure During High-Volume CRRT for Hyperammonaemia: A Case Report.
van Herwerden MC, Elderman JH, Favie LMA, Wagenmakers M
Case reports in critical care, 2026
Abstract
Hyperammonaemic decompensation in urea cycle disorders (UCDs) is a medical emergency that requires prompt intervention. Continuous renal replacement therapy (CRRT) is an effective strategy for acute ammonia clearance, but it may significantly alter the pharmacokinetics of administered drugs.